Comparing dynamics and determinants of SARS-CoV-2 transmissions among health care workers of adult and pediatric settings in central Paris.
Identifieur interne : 001290 ( Main/Exploration ); précédent : 001289; suivant : 001291Comparing dynamics and determinants of SARS-CoV-2 transmissions among health care workers of adult and pediatric settings in central Paris.
Auteurs : Adrien Contejean [France] ; Jérémie Leporrier [France] ; Etienne Canouï [France] ; Fanny Alby-Laurent [France] ; Emmanuel Lafont [France] ; Lauren Beaudeau [France] ; Perrine Parize [France] ; Fabienne Lecieux [France] ; Agnès Greffet [France] ; Gérard Chéron [France] ; Rémy Gauzit [France] ; Jacques Fourgeaud [France] ; Anne-Sophie L'Honneur [France] ; Jean-Marc Tréluyer [France] ; Caroline Charlier [France] ; Anne Casetta [France] ; Pierre Frange [France] ; Marianne Leruez-Ville [France] ; Flore Rozenberg [France] ; Olivier Lortholary [France] ; Solen Kernéis [France]Source :
- Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [ 1537-6591 ] ; 2020.
Abstract
BACKGROUND
Health-care workers (HCW) have paid a heavy toll to the coronavirus disease-19 (COVID-19) outbreak. Routes of transmission remain to be fully understood.
METHODS
This prospective study compared a 1,500-bed adult and a 600-bed pediatric setting of a tertiary-care university hospital located in central Paris. From February 24th until April 10th, 2020, all symptomatic HCW were screened for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) on a nasopharyngeal swab. HCW screened positive were questioned on their profession, symptoms, occupational and non-occupational exposures to SARS-CoV-2.
RESULTS
Among 1344 HCW tested, 373 were positive (28%) and 336 (90%) corresponding questionnaires were completed. Three hospitalizations and no death were reported. Most HCW (70%) had patient-facing occupational activities (22% in COVID-19 dedicated units). The total number of HCW cases peaked on March 23rd, then decreased slowly, concomitantly with a continuous increase of compliance to preventive measures (including universal medical masking and personal protective equipment (PPE) for direct care to COVID-19 patients). Attack rates were of 3.2% and 2.3% in the adult and pediatric setting, respectively (p=0.0022). In the adult setting, HCW more frequently reported exposure to COVID-19 patients without PPE (25% versus 15%, p=0.046). Report of contacts with children attending out-of-home care facilities dramatically decreased over the study period.
CONCLUSION
Universal masking, reinforcement of hand hygiene, and PPE with medical masks for patients' care allowed protection of HCW and containment of the outbreak. Residual transmissions were related to persistent exposures with undiagnosed patients or colleagues and not to contacts with children attending out-of-home care facilities.
DOI: 10.1093/cid/ciaa977
PubMed: 32663849
PubMed Central: PMC7454459
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Comparing dynamics and determinants of SARS-CoV-2 transmissions among health care workers of adult and pediatric settings in central Paris.</title><author><name sortKey="Contejean, Adrien" sort="Contejean, Adrien" uniqKey="Contejean A" first="Adrien" last="Contejean">Adrien Contejean</name><affiliation wicri:level="3"><nlm:affiliation>Université de Paris, Faculté de Médecine, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université de Paris, Faculté de Médecine, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Equipe Mobile d'Infectiologie, AP-HP, Hôpital Cochin, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Equipe Mobile d'Infectiologie, AP-HP, Hôpital Cochin, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Leporrier, Jeremie" sort="Leporrier, Jeremie" uniqKey="Leporrier J" first="Jérémie" last="Leporrier">Jérémie Leporrier</name><affiliation wicri:level="3"><nlm:affiliation>Service de maladies infectieuses et tropicales, AP-HP, IHU Imagine, Hôpital Necker-Enfants malades, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de maladies infectieuses et tropicales, AP-HP, IHU Imagine, Hôpital Necker-Enfants malades, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Canoui, Etienne" sort="Canoui, Etienne" uniqKey="Canoui E" first="Etienne" last="Canouï">Etienne Canouï</name><affiliation wicri:level="3"><nlm:affiliation>Equipe Mobile d'Infectiologie, AP-HP, Hôpital Cochin, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Equipe Mobile d'Infectiologie, AP-HP, Hôpital Cochin, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Alby Laurent, Fanny" sort="Alby Laurent, Fanny" uniqKey="Alby Laurent F" first="Fanny" last="Alby-Laurent">Fanny Alby-Laurent</name><affiliation wicri:level="3"><nlm:affiliation>Université de Paris, Faculté de Médecine, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université de Paris, Faculté de Médecine, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Service de maladies infectieuses et tropicales, AP-HP, IHU Imagine, Hôpital Necker-Enfants malades, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de maladies infectieuses et tropicales, AP-HP, IHU Imagine, Hôpital Necker-Enfants malades, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Lafont, Emmanuel" sort="Lafont, Emmanuel" uniqKey="Lafont E" first="Emmanuel" last="Lafont">Emmanuel Lafont</name><affiliation wicri:level="3"><nlm:affiliation>Université de Paris, Faculté de Médecine, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université de Paris, Faculté de Médecine, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Service de maladies infectieuses et tropicales, AP-HP, IHU Imagine, Hôpital Necker-Enfants malades, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de maladies infectieuses et tropicales, AP-HP, IHU Imagine, Hôpital Necker-Enfants malades, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Beaudeau, Lauren" sort="Beaudeau, Lauren" uniqKey="Beaudeau L" first="Lauren" last="Beaudeau">Lauren Beaudeau</name><affiliation wicri:level="3"><nlm:affiliation>Equipe Mobile d'Infectiologie, AP-HP, Hôpital Cochin, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Equipe Mobile d'Infectiologie, AP-HP, Hôpital Cochin, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Parize, Perrine" sort="Parize, Perrine" uniqKey="Parize P" first="Perrine" last="Parize">Perrine Parize</name><affiliation wicri:level="3"><nlm:affiliation>Service de maladies infectieuses et tropicales, AP-HP, IHU Imagine, Hôpital Necker-Enfants malades, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de maladies infectieuses et tropicales, AP-HP, IHU Imagine, Hôpital Necker-Enfants malades, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Lecieux, Fabienne" sort="Lecieux, Fabienne" uniqKey="Lecieux F" first="Fabienne" last="Lecieux">Fabienne Lecieux</name><affiliation wicri:level="3"><nlm:affiliation>Service de santé au travail, AP-HP, Hôpital Cochin, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de santé au travail, AP-HP, Hôpital Cochin, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Greffet, Agnes" sort="Greffet, Agnes" uniqKey="Greffet A" first="Agnès" last="Greffet">Agnès Greffet</name><affiliation wicri:level="3"><nlm:affiliation>Service de santé au travail, AP-HP, Hôpital Necker-Enfants malades, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de santé au travail, AP-HP, Hôpital Necker-Enfants malades, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Cheron, Gerard" sort="Cheron, Gerard" uniqKey="Cheron G" first="Gérard" last="Chéron">Gérard Chéron</name><affiliation wicri:level="3"><nlm:affiliation>Université de Paris, Faculté de Médecine, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université de Paris, Faculté de Médecine, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Service d'urgences pédiatriques, AP-HP, Hôpital Necker-Enfants malades, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service d'urgences pédiatriques, AP-HP, Hôpital Necker-Enfants malades, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Gauzit, Remy" sort="Gauzit, Remy" uniqKey="Gauzit R" first="Rémy" last="Gauzit">Rémy Gauzit</name><affiliation wicri:level="3"><nlm:affiliation>Equipe Mobile d'Infectiologie, AP-HP, Hôpital Cochin, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Equipe Mobile d'Infectiologie, AP-HP, Hôpital Cochin, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Fourgeaud, Jacques" sort="Fourgeaud, Jacques" uniqKey="Fourgeaud J" first="Jacques" last="Fourgeaud">Jacques Fourgeaud</name><affiliation wicri:level="3"><nlm:affiliation>Laboratoire de virologie, AP-HP, Hôpital Necker-Enfants malades, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de virologie, AP-HP, Hôpital Necker-Enfants malades, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>EHU 7328 PACT, Institut Imagine, Université de Paris, Faculté de Médecine, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>EHU 7328 PACT, Institut Imagine, Université de Paris, Faculté de Médecine, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="L Honneur, Anne Sophie" sort="L Honneur, Anne Sophie" uniqKey="L Honneur A" first="Anne-Sophie" last="L'Honneur">Anne-Sophie L'Honneur</name><affiliation wicri:level="3"><nlm:affiliation>Département de virologie, AP-HP, Hôpital Cochin, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Département de virologie, AP-HP, Hôpital Cochin, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Treluyer, Jean Marc" sort="Treluyer, Jean Marc" uniqKey="Treluyer J" first="Jean-Marc" last="Tréluyer">Jean-Marc Tréluyer</name><affiliation wicri:level="3"><nlm:affiliation>Département de soins intensifs pédiatriques, AP-HP, Hôpital Necker-Enfants malades, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Département de soins intensifs pédiatriques, AP-HP, Hôpital Necker-Enfants malades, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Pharmacology and Drug Evaluation in Children and Pregnant Women EA, Université de Paris, Faculté de Médecine, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Pharmacology and Drug Evaluation in Children and Pregnant Women EA, Université de Paris, Faculté de Médecine, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Département de pharmacologie clinique AP-HP, Hôpital Cochin, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Département de pharmacologie clinique AP-HP, Hôpital Cochin, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Charlier, Caroline" sort="Charlier, Caroline" uniqKey="Charlier C" first="Caroline" last="Charlier">Caroline Charlier</name><affiliation wicri:level="3"><nlm:affiliation>Université de Paris, Faculté de Médecine, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université de Paris, Faculté de Médecine, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Service de maladies infectieuses et tropicales, AP-HP, IHU Imagine, Hôpital Necker-Enfants malades, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de maladies infectieuses et tropicales, AP-HP, IHU Imagine, Hôpital Necker-Enfants malades, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Casetta, Anne" sort="Casetta, Anne" uniqKey="Casetta A" first="Anne" last="Casetta">Anne Casetta</name><affiliation wicri:level="3"><nlm:affiliation>Equipe opérationnelle d'hygiène hospitalière, AP-HP, Hôpital Cochin, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Equipe opérationnelle d'hygiène hospitalière, AP-HP, Hôpital Cochin, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Frange, Pierre" sort="Frange, Pierre" uniqKey="Frange P" first="Pierre" last="Frange">Pierre Frange</name><affiliation wicri:level="3"><nlm:affiliation>EHU 7328 PACT, Institut Imagine, Université de Paris, Faculté de Médecine, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>EHU 7328 PACT, Institut Imagine, Université de Paris, Faculté de Médecine, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Laboratoire de microbiologie clinique, AP-HP, Hôpital Necker-Enfants malades, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de microbiologie clinique, AP-HP, Hôpital Necker-Enfants malades, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Leruez Ville, Marianne" sort="Leruez Ville, Marianne" uniqKey="Leruez Ville M" first="Marianne" last="Leruez-Ville">Marianne Leruez-Ville</name><affiliation wicri:level="3"><nlm:affiliation>Laboratoire de virologie, AP-HP, Hôpital Necker-Enfants malades, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de virologie, AP-HP, Hôpital Necker-Enfants malades, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>EHU 7328 PACT, Institut Imagine, Université de Paris, Faculté de Médecine, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>EHU 7328 PACT, Institut Imagine, Université de Paris, Faculté de Médecine, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Rozenberg, Flore" sort="Rozenberg, Flore" uniqKey="Rozenberg F" first="Flore" last="Rozenberg">Flore Rozenberg</name><affiliation wicri:level="3"><nlm:affiliation>Equipe Mobile d'Infectiologie, AP-HP, Hôpital Cochin, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Equipe Mobile d'Infectiologie, AP-HP, Hôpital Cochin, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Département de virologie, AP-HP, Hôpital Cochin, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Département de virologie, AP-HP, Hôpital Cochin, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Lortholary, Olivier" sort="Lortholary, Olivier" uniqKey="Lortholary O" first="Olivier" last="Lortholary">Olivier Lortholary</name><affiliation wicri:level="3"><nlm:affiliation>Université de Paris, Faculté de Médecine, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université de Paris, Faculté de Médecine, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Service de maladies infectieuses et tropicales, AP-HP, IHU Imagine, Hôpital Necker-Enfants malades, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de maladies infectieuses et tropicales, AP-HP, IHU Imagine, Hôpital Necker-Enfants malades, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Institut Pasteur, Molecular Mycology Unit, National Reference Centre for Invasive Mycoses and Antifungals, CNRS UMR, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut Pasteur, Molecular Mycology Unit, National Reference Centre for Invasive Mycoses and Antifungals, CNRS UMR, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Kerneis, Solen" sort="Kerneis, Solen" uniqKey="Kerneis S" first="Solen" last="Kernéis">Solen Kernéis</name><affiliation wicri:level="3"><nlm:affiliation>Université de Paris, Faculté de Médecine, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université de Paris, Faculté de Médecine, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Equipe Mobile d'Infectiologie, AP-HP, Hôpital Cochin, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Equipe Mobile d'Infectiologie, AP-HP, Hôpital Cochin, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Epidemiology and modelling of bacterial escape to antimicrobials (EMEA), Institut Pasteur , Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Epidemiology and modelling of bacterial escape to antimicrobials (EMEA), Institut Pasteur , Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32663849</idno><idno type="pmid">32663849</idno><idno type="doi">10.1093/cid/ciaa977</idno><idno type="pmc">PMC7454459</idno><idno type="wicri:Area/Main/Corpus">000983</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000983</idno><idno type="wicri:Area/Main/Curation">000983</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000983</idno><idno type="wicri:Area/Main/Exploration">000983</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Comparing dynamics and determinants of SARS-CoV-2 transmissions among health care workers of adult and pediatric settings in central Paris.</title><author><name sortKey="Contejean, Adrien" sort="Contejean, Adrien" uniqKey="Contejean A" first="Adrien" last="Contejean">Adrien Contejean</name><affiliation wicri:level="3"><nlm:affiliation>Université de Paris, Faculté de Médecine, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université de Paris, Faculté de Médecine, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Equipe Mobile d'Infectiologie, AP-HP, Hôpital Cochin, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Equipe Mobile d'Infectiologie, AP-HP, Hôpital Cochin, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Leporrier, Jeremie" sort="Leporrier, Jeremie" uniqKey="Leporrier J" first="Jérémie" last="Leporrier">Jérémie Leporrier</name><affiliation wicri:level="3"><nlm:affiliation>Service de maladies infectieuses et tropicales, AP-HP, IHU Imagine, Hôpital Necker-Enfants malades, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de maladies infectieuses et tropicales, AP-HP, IHU Imagine, Hôpital Necker-Enfants malades, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Canoui, Etienne" sort="Canoui, Etienne" uniqKey="Canoui E" first="Etienne" last="Canouï">Etienne Canouï</name><affiliation wicri:level="3"><nlm:affiliation>Equipe Mobile d'Infectiologie, AP-HP, Hôpital Cochin, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Equipe Mobile d'Infectiologie, AP-HP, Hôpital Cochin, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Alby Laurent, Fanny" sort="Alby Laurent, Fanny" uniqKey="Alby Laurent F" first="Fanny" last="Alby-Laurent">Fanny Alby-Laurent</name><affiliation wicri:level="3"><nlm:affiliation>Université de Paris, Faculté de Médecine, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université de Paris, Faculté de Médecine, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Service de maladies infectieuses et tropicales, AP-HP, IHU Imagine, Hôpital Necker-Enfants malades, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de maladies infectieuses et tropicales, AP-HP, IHU Imagine, Hôpital Necker-Enfants malades, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Lafont, Emmanuel" sort="Lafont, Emmanuel" uniqKey="Lafont E" first="Emmanuel" last="Lafont">Emmanuel Lafont</name><affiliation wicri:level="3"><nlm:affiliation>Université de Paris, Faculté de Médecine, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université de Paris, Faculté de Médecine, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Service de maladies infectieuses et tropicales, AP-HP, IHU Imagine, Hôpital Necker-Enfants malades, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de maladies infectieuses et tropicales, AP-HP, IHU Imagine, Hôpital Necker-Enfants malades, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Beaudeau, Lauren" sort="Beaudeau, Lauren" uniqKey="Beaudeau L" first="Lauren" last="Beaudeau">Lauren Beaudeau</name><affiliation wicri:level="3"><nlm:affiliation>Equipe Mobile d'Infectiologie, AP-HP, Hôpital Cochin, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Equipe Mobile d'Infectiologie, AP-HP, Hôpital Cochin, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Parize, Perrine" sort="Parize, Perrine" uniqKey="Parize P" first="Perrine" last="Parize">Perrine Parize</name><affiliation wicri:level="3"><nlm:affiliation>Service de maladies infectieuses et tropicales, AP-HP, IHU Imagine, Hôpital Necker-Enfants malades, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de maladies infectieuses et tropicales, AP-HP, IHU Imagine, Hôpital Necker-Enfants malades, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Lecieux, Fabienne" sort="Lecieux, Fabienne" uniqKey="Lecieux F" first="Fabienne" last="Lecieux">Fabienne Lecieux</name><affiliation wicri:level="3"><nlm:affiliation>Service de santé au travail, AP-HP, Hôpital Cochin, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de santé au travail, AP-HP, Hôpital Cochin, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Greffet, Agnes" sort="Greffet, Agnes" uniqKey="Greffet A" first="Agnès" last="Greffet">Agnès Greffet</name><affiliation wicri:level="3"><nlm:affiliation>Service de santé au travail, AP-HP, Hôpital Necker-Enfants malades, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de santé au travail, AP-HP, Hôpital Necker-Enfants malades, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Cheron, Gerard" sort="Cheron, Gerard" uniqKey="Cheron G" first="Gérard" last="Chéron">Gérard Chéron</name><affiliation wicri:level="3"><nlm:affiliation>Université de Paris, Faculté de Médecine, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université de Paris, Faculté de Médecine, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Service d'urgences pédiatriques, AP-HP, Hôpital Necker-Enfants malades, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service d'urgences pédiatriques, AP-HP, Hôpital Necker-Enfants malades, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Gauzit, Remy" sort="Gauzit, Remy" uniqKey="Gauzit R" first="Rémy" last="Gauzit">Rémy Gauzit</name><affiliation wicri:level="3"><nlm:affiliation>Equipe Mobile d'Infectiologie, AP-HP, Hôpital Cochin, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Equipe Mobile d'Infectiologie, AP-HP, Hôpital Cochin, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Fourgeaud, Jacques" sort="Fourgeaud, Jacques" uniqKey="Fourgeaud J" first="Jacques" last="Fourgeaud">Jacques Fourgeaud</name><affiliation wicri:level="3"><nlm:affiliation>Laboratoire de virologie, AP-HP, Hôpital Necker-Enfants malades, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de virologie, AP-HP, Hôpital Necker-Enfants malades, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>EHU 7328 PACT, Institut Imagine, Université de Paris, Faculté de Médecine, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>EHU 7328 PACT, Institut Imagine, Université de Paris, Faculté de Médecine, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="L Honneur, Anne Sophie" sort="L Honneur, Anne Sophie" uniqKey="L Honneur A" first="Anne-Sophie" last="L'Honneur">Anne-Sophie L'Honneur</name><affiliation wicri:level="3"><nlm:affiliation>Département de virologie, AP-HP, Hôpital Cochin, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Département de virologie, AP-HP, Hôpital Cochin, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Treluyer, Jean Marc" sort="Treluyer, Jean Marc" uniqKey="Treluyer J" first="Jean-Marc" last="Tréluyer">Jean-Marc Tréluyer</name><affiliation wicri:level="3"><nlm:affiliation>Département de soins intensifs pédiatriques, AP-HP, Hôpital Necker-Enfants malades, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Département de soins intensifs pédiatriques, AP-HP, Hôpital Necker-Enfants malades, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Pharmacology and Drug Evaluation in Children and Pregnant Women EA, Université de Paris, Faculté de Médecine, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Pharmacology and Drug Evaluation in Children and Pregnant Women EA, Université de Paris, Faculté de Médecine, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Département de pharmacologie clinique AP-HP, Hôpital Cochin, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Département de pharmacologie clinique AP-HP, Hôpital Cochin, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Charlier, Caroline" sort="Charlier, Caroline" uniqKey="Charlier C" first="Caroline" last="Charlier">Caroline Charlier</name><affiliation wicri:level="3"><nlm:affiliation>Université de Paris, Faculté de Médecine, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université de Paris, Faculté de Médecine, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Service de maladies infectieuses et tropicales, AP-HP, IHU Imagine, Hôpital Necker-Enfants malades, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de maladies infectieuses et tropicales, AP-HP, IHU Imagine, Hôpital Necker-Enfants malades, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Casetta, Anne" sort="Casetta, Anne" uniqKey="Casetta A" first="Anne" last="Casetta">Anne Casetta</name><affiliation wicri:level="3"><nlm:affiliation>Equipe opérationnelle d'hygiène hospitalière, AP-HP, Hôpital Cochin, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Equipe opérationnelle d'hygiène hospitalière, AP-HP, Hôpital Cochin, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Frange, Pierre" sort="Frange, Pierre" uniqKey="Frange P" first="Pierre" last="Frange">Pierre Frange</name><affiliation wicri:level="3"><nlm:affiliation>EHU 7328 PACT, Institut Imagine, Université de Paris, Faculté de Médecine, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>EHU 7328 PACT, Institut Imagine, Université de Paris, Faculté de Médecine, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Laboratoire de microbiologie clinique, AP-HP, Hôpital Necker-Enfants malades, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de microbiologie clinique, AP-HP, Hôpital Necker-Enfants malades, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Leruez Ville, Marianne" sort="Leruez Ville, Marianne" uniqKey="Leruez Ville M" first="Marianne" last="Leruez-Ville">Marianne Leruez-Ville</name><affiliation wicri:level="3"><nlm:affiliation>Laboratoire de virologie, AP-HP, Hôpital Necker-Enfants malades, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de virologie, AP-HP, Hôpital Necker-Enfants malades, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>EHU 7328 PACT, Institut Imagine, Université de Paris, Faculté de Médecine, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>EHU 7328 PACT, Institut Imagine, Université de Paris, Faculté de Médecine, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Rozenberg, Flore" sort="Rozenberg, Flore" uniqKey="Rozenberg F" first="Flore" last="Rozenberg">Flore Rozenberg</name><affiliation wicri:level="3"><nlm:affiliation>Equipe Mobile d'Infectiologie, AP-HP, Hôpital Cochin, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Equipe Mobile d'Infectiologie, AP-HP, Hôpital Cochin, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Département de virologie, AP-HP, Hôpital Cochin, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Département de virologie, AP-HP, Hôpital Cochin, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Lortholary, Olivier" sort="Lortholary, Olivier" uniqKey="Lortholary O" first="Olivier" last="Lortholary">Olivier Lortholary</name><affiliation wicri:level="3"><nlm:affiliation>Université de Paris, Faculté de Médecine, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université de Paris, Faculté de Médecine, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Service de maladies infectieuses et tropicales, AP-HP, IHU Imagine, Hôpital Necker-Enfants malades, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de maladies infectieuses et tropicales, AP-HP, IHU Imagine, Hôpital Necker-Enfants malades, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Institut Pasteur, Molecular Mycology Unit, National Reference Centre for Invasive Mycoses and Antifungals, CNRS UMR, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut Pasteur, Molecular Mycology Unit, National Reference Centre for Invasive Mycoses and Antifungals, CNRS UMR, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Kerneis, Solen" sort="Kerneis, Solen" uniqKey="Kerneis S" first="Solen" last="Kernéis">Solen Kernéis</name><affiliation wicri:level="3"><nlm:affiliation>Université de Paris, Faculté de Médecine, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université de Paris, Faculté de Médecine, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Equipe Mobile d'Infectiologie, AP-HP, Hôpital Cochin, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Equipe Mobile d'Infectiologie, AP-HP, Hôpital Cochin, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Epidemiology and modelling of bacterial escape to antimicrobials (EMEA), Institut Pasteur , Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Epidemiology and modelling of bacterial escape to antimicrobials (EMEA), Institut Pasteur , Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author></analytic><series><title level="j">Clinical infectious diseases : an official publication of the Infectious Diseases Society of America</title><idno type="eISSN">1537-6591</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b></p><p>Health-care workers (HCW) have paid a heavy toll to the coronavirus disease-19 (COVID-19) outbreak. Routes of transmission remain to be fully understood.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>This prospective study compared a 1,500-bed adult and a 600-bed pediatric setting of a tertiary-care university hospital located in central Paris. From February 24th until April 10th, 2020, all symptomatic HCW were screened for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) on a nasopharyngeal swab. HCW screened positive were questioned on their profession, symptoms, occupational and non-occupational exposures to SARS-CoV-2.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>Among 1344 HCW tested, 373 were positive (28%) and 336 (90%) corresponding questionnaires were completed. Three hospitalizations and no death were reported. Most HCW (70%) had patient-facing occupational activities (22% in COVID-19 dedicated units). The total number of HCW cases peaked on March 23rd, then decreased slowly, concomitantly with a continuous increase of compliance to preventive measures (including universal medical masking and personal protective equipment (PPE) for direct care to COVID-19 patients). Attack rates were of 3.2% and 2.3% in the adult and pediatric setting, respectively (p=0.0022). In the adult setting, HCW more frequently reported exposure to COVID-19 patients without PPE (25% versus 15%, p=0.046). Report of contacts with children attending out-of-home care facilities dramatically decreased over the study period.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSION</b></p><p>Universal masking, reinforcement of hand hygiene, and PPE with medical masks for patients' care allowed protection of HCW and containment of the outbreak. Residual transmissions were related to persistent exposures with undiagnosed patients or colleagues and not to contacts with children attending out-of-home care facilities.</p></div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">32663849</PMID><DateRevised><Year>2020</Year><Month>09</Month><Day>01</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1537-6591</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2020</Year><Month>Jul</Month><Day>15</Day></PubDate></JournalIssue><Title>Clinical infectious diseases : an official publication of the Infectious Diseases Society of America</Title><ISOAbbreviation>Clin. Infect. Dis.</ISOAbbreviation></Journal><ArticleTitle>Comparing dynamics and determinants of SARS-CoV-2 transmissions among health care workers of adult and pediatric settings in central Paris.</ArticleTitle><ELocationID EIdType="pii" ValidYN="Y">ciaa977</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1093/cid/ciaa977</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Health-care workers (HCW) have paid a heavy toll to the coronavirus disease-19 (COVID-19) outbreak. Routes of transmission remain to be fully understood.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">This prospective study compared a 1,500-bed adult and a 600-bed pediatric setting of a tertiary-care university hospital located in central Paris. From February 24th until April 10th, 2020, all symptomatic HCW were screened for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) on a nasopharyngeal swab. HCW screened positive were questioned on their profession, symptoms, occupational and non-occupational exposures to SARS-CoV-2.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Among 1344 HCW tested, 373 were positive (28%) and 336 (90%) corresponding questionnaires were completed. Three hospitalizations and no death were reported. Most HCW (70%) had patient-facing occupational activities (22% in COVID-19 dedicated units). The total number of HCW cases peaked on March 23rd, then decreased slowly, concomitantly with a continuous increase of compliance to preventive measures (including universal medical masking and personal protective equipment (PPE) for direct care to COVID-19 patients). Attack rates were of 3.2% and 2.3% in the adult and pediatric setting, respectively (p=0.0022). In the adult setting, HCW more frequently reported exposure to COVID-19 patients without PPE (25% versus 15%, p=0.046). Report of contacts with children attending out-of-home care facilities dramatically decreased over the study period.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Universal masking, reinforcement of hand hygiene, and PPE with medical masks for patients' care allowed protection of HCW and containment of the outbreak. Residual transmissions were related to persistent exposures with undiagnosed patients or colleagues and not to contacts with children attending out-of-home care facilities.</AbstractText><CopyrightInformation>© The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Contejean</LastName><ForeName>Adrien</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Université de Paris, Faculté de Médecine, Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Equipe Mobile d'Infectiologie, AP-HP, Hôpital Cochin, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Leporrier</LastName><ForeName>Jérémie</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Service de maladies infectieuses et tropicales, AP-HP, IHU Imagine, Hôpital Necker-Enfants malades, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Canouï</LastName><ForeName>Etienne</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Equipe Mobile d'Infectiologie, AP-HP, Hôpital Cochin, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Alby-Laurent</LastName><ForeName>Fanny</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Université de Paris, Faculté de Médecine, Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Service de maladies infectieuses et tropicales, AP-HP, IHU Imagine, Hôpital Necker-Enfants malades, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lafont</LastName><ForeName>Emmanuel</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Université de Paris, Faculté de Médecine, Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Service de maladies infectieuses et tropicales, AP-HP, IHU Imagine, Hôpital Necker-Enfants malades, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Beaudeau</LastName><ForeName>Lauren</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Equipe Mobile d'Infectiologie, AP-HP, Hôpital Cochin, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Parize</LastName><ForeName>Perrine</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Service de maladies infectieuses et tropicales, AP-HP, IHU Imagine, Hôpital Necker-Enfants malades, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lecieux</LastName><ForeName>Fabienne</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Service de santé au travail, AP-HP, Hôpital Cochin, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Greffet</LastName><ForeName>Agnès</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Service de santé au travail, AP-HP, Hôpital Necker-Enfants malades, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chéron</LastName><ForeName>Gérard</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Université de Paris, Faculté de Médecine, Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Service d'urgences pédiatriques, AP-HP, Hôpital Necker-Enfants malades, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gauzit</LastName><ForeName>Rémy</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Equipe Mobile d'Infectiologie, AP-HP, Hôpital Cochin, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fourgeaud</LastName><ForeName>Jacques</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Laboratoire de virologie, AP-HP, Hôpital Necker-Enfants malades, Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>EHU 7328 PACT, Institut Imagine, Université de Paris, Faculté de Médecine, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>L'Honneur</LastName><ForeName>Anne-Sophie</ForeName><Initials>AS</Initials><AffiliationInfo><Affiliation>Département de virologie, AP-HP, Hôpital Cochin, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tréluyer</LastName><ForeName>Jean-Marc</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>Département de soins intensifs pédiatriques, AP-HP, Hôpital Necker-Enfants malades, Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Pharmacology and Drug Evaluation in Children and Pregnant Women EA, Université de Paris, Faculté de Médecine, Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Département de pharmacologie clinique AP-HP, Hôpital Cochin, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Charlier</LastName><ForeName>Caroline</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Université de Paris, Faculté de Médecine, Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Service de maladies infectieuses et tropicales, AP-HP, IHU Imagine, Hôpital Necker-Enfants malades, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Casetta</LastName><ForeName>Anne</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Equipe opérationnelle d'hygiène hospitalière, AP-HP, Hôpital Cochin, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Frange</LastName><ForeName>Pierre</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>EHU 7328 PACT, Institut Imagine, Université de Paris, Faculté de Médecine, Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Laboratoire de microbiologie clinique, AP-HP, Hôpital Necker-Enfants malades, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Leruez-Ville</LastName><ForeName>Marianne</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Laboratoire de virologie, AP-HP, Hôpital Necker-Enfants malades, Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>EHU 7328 PACT, Institut Imagine, Université de Paris, Faculté de Médecine, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rozenberg</LastName><ForeName>Flore</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Equipe Mobile d'Infectiologie, AP-HP, Hôpital Cochin, Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Département de virologie, AP-HP, Hôpital Cochin, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lortholary</LastName><ForeName>Olivier</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>Université de Paris, Faculté de Médecine, Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Service de maladies infectieuses et tropicales, AP-HP, IHU Imagine, Hôpital Necker-Enfants malades, Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institut Pasteur, Molecular Mycology Unit, National Reference Centre for Invasive Mycoses and Antifungals, CNRS UMR, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kernéis</LastName><ForeName>Solen</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Université de Paris, Faculté de Médecine, Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Equipe Mobile d'Infectiologie, AP-HP, Hôpital Cochin, Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Epidemiology and modelling of bacterial escape to antimicrobials (EMEA), Institut Pasteur , Paris, France.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>07</Month><Day>15</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Clin Infect Dis</MedlineTA><NlmUniqueID>9203213</NlmUniqueID><ISSNLinking>1058-4838</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">COVID-19</Keyword><Keyword MajorTopicYN="N">Determinants</Keyword><Keyword MajorTopicYN="N">Dynamics</Keyword><Keyword MajorTopicYN="N">Health Care Workers</Keyword><Keyword MajorTopicYN="N">SARS-CoV-2</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>05</Month><Day>22</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>7</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>7</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>7</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32663849</ArticleId><ArticleId IdType="pii">5871438</ArticleId><ArticleId IdType="doi">10.1093/cid/ciaa977</ArticleId><ArticleId IdType="pmc">PMC7454459</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>France</li></country><region><li>Île-de-France</li></region><settlement><li>Paris</li></settlement></list><tree><country name="France"><region name="Île-de-France"><name sortKey="Contejean, Adrien" sort="Contejean, Adrien" uniqKey="Contejean A" first="Adrien" last="Contejean">Adrien Contejean</name></region><name sortKey="Alby Laurent, Fanny" sort="Alby Laurent, Fanny" uniqKey="Alby Laurent F" first="Fanny" last="Alby-Laurent">Fanny Alby-Laurent</name><name sortKey="Alby Laurent, Fanny" sort="Alby Laurent, Fanny" uniqKey="Alby Laurent F" first="Fanny" last="Alby-Laurent">Fanny Alby-Laurent</name><name sortKey="Beaudeau, Lauren" sort="Beaudeau, Lauren" uniqKey="Beaudeau L" first="Lauren" last="Beaudeau">Lauren Beaudeau</name><name sortKey="Canoui, Etienne" sort="Canoui, Etienne" uniqKey="Canoui E" first="Etienne" last="Canouï">Etienne Canouï</name><name sortKey="Casetta, Anne" sort="Casetta, Anne" uniqKey="Casetta A" first="Anne" last="Casetta">Anne Casetta</name><name sortKey="Charlier, Caroline" sort="Charlier, Caroline" uniqKey="Charlier C" first="Caroline" last="Charlier">Caroline Charlier</name><name sortKey="Charlier, Caroline" sort="Charlier, Caroline" uniqKey="Charlier C" first="Caroline" last="Charlier">Caroline Charlier</name><name sortKey="Cheron, Gerard" sort="Cheron, Gerard" uniqKey="Cheron G" first="Gérard" last="Chéron">Gérard Chéron</name><name sortKey="Cheron, Gerard" sort="Cheron, Gerard" uniqKey="Cheron G" first="Gérard" last="Chéron">Gérard Chéron</name><name sortKey="Contejean, Adrien" sort="Contejean, Adrien" uniqKey="Contejean A" first="Adrien" last="Contejean">Adrien Contejean</name><name sortKey="Fourgeaud, Jacques" sort="Fourgeaud, Jacques" uniqKey="Fourgeaud J" first="Jacques" last="Fourgeaud">Jacques Fourgeaud</name><name sortKey="Fourgeaud, Jacques" sort="Fourgeaud, Jacques" uniqKey="Fourgeaud J" first="Jacques" last="Fourgeaud">Jacques Fourgeaud</name><name sortKey="Frange, Pierre" sort="Frange, Pierre" uniqKey="Frange P" first="Pierre" last="Frange">Pierre Frange</name><name sortKey="Frange, Pierre" sort="Frange, Pierre" uniqKey="Frange P" first="Pierre" last="Frange">Pierre Frange</name><name sortKey="Gauzit, Remy" sort="Gauzit, Remy" uniqKey="Gauzit R" first="Rémy" last="Gauzit">Rémy Gauzit</name><name sortKey="Greffet, Agnes" sort="Greffet, Agnes" uniqKey="Greffet A" first="Agnès" last="Greffet">Agnès Greffet</name><name sortKey="Kerneis, Solen" sort="Kerneis, Solen" uniqKey="Kerneis S" first="Solen" last="Kernéis">Solen Kernéis</name><name sortKey="Kerneis, Solen" sort="Kerneis, Solen" uniqKey="Kerneis S" first="Solen" last="Kernéis">Solen Kernéis</name><name sortKey="Kerneis, Solen" sort="Kerneis, Solen" uniqKey="Kerneis S" first="Solen" last="Kernéis">Solen Kernéis</name><name sortKey="L Honneur, Anne Sophie" sort="L Honneur, Anne Sophie" uniqKey="L Honneur A" first="Anne-Sophie" last="L'Honneur">Anne-Sophie L'Honneur</name><name sortKey="Lafont, Emmanuel" sort="Lafont, Emmanuel" uniqKey="Lafont E" first="Emmanuel" last="Lafont">Emmanuel Lafont</name><name sortKey="Lafont, Emmanuel" sort="Lafont, Emmanuel" uniqKey="Lafont E" first="Emmanuel" last="Lafont">Emmanuel Lafont</name><name sortKey="Lecieux, Fabienne" sort="Lecieux, Fabienne" uniqKey="Lecieux F" first="Fabienne" last="Lecieux">Fabienne Lecieux</name><name sortKey="Leporrier, Jeremie" sort="Leporrier, Jeremie" uniqKey="Leporrier J" first="Jérémie" last="Leporrier">Jérémie Leporrier</name><name sortKey="Leruez Ville, Marianne" sort="Leruez Ville, Marianne" uniqKey="Leruez Ville M" first="Marianne" last="Leruez-Ville">Marianne Leruez-Ville</name><name sortKey="Leruez Ville, Marianne" sort="Leruez Ville, Marianne" uniqKey="Leruez Ville M" first="Marianne" last="Leruez-Ville">Marianne Leruez-Ville</name><name sortKey="Lortholary, Olivier" sort="Lortholary, Olivier" uniqKey="Lortholary O" first="Olivier" last="Lortholary">Olivier Lortholary</name><name sortKey="Lortholary, Olivier" sort="Lortholary, Olivier" uniqKey="Lortholary O" first="Olivier" last="Lortholary">Olivier Lortholary</name><name sortKey="Lortholary, Olivier" sort="Lortholary, Olivier" uniqKey="Lortholary O" first="Olivier" last="Lortholary">Olivier Lortholary</name><name sortKey="Parize, Perrine" sort="Parize, Perrine" uniqKey="Parize P" first="Perrine" last="Parize">Perrine Parize</name><name sortKey="Rozenberg, Flore" sort="Rozenberg, Flore" uniqKey="Rozenberg F" first="Flore" last="Rozenberg">Flore Rozenberg</name><name sortKey="Rozenberg, Flore" sort="Rozenberg, Flore" uniqKey="Rozenberg F" first="Flore" last="Rozenberg">Flore Rozenberg</name><name sortKey="Treluyer, Jean Marc" sort="Treluyer, Jean Marc" uniqKey="Treluyer J" first="Jean-Marc" last="Tréluyer">Jean-Marc Tréluyer</name><name sortKey="Treluyer, Jean Marc" sort="Treluyer, Jean Marc" uniqKey="Treluyer J" first="Jean-Marc" last="Tréluyer">Jean-Marc Tréluyer</name><name sortKey="Treluyer, Jean Marc" sort="Treluyer, Jean Marc" uniqKey="Treluyer J" first="Jean-Marc" last="Tréluyer">Jean-Marc Tréluyer</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/CovidFranceV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001290 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001290 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= CovidFranceV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:32663849
|texte= Comparing dynamics and determinants of SARS-CoV-2 transmissions among health care workers of adult and pediatric settings in central Paris.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:32663849" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a CovidFranceV1
| This area was generated with Dilib version V0.6.37. |  |